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BCH Order Code LAB438 Electrophoresis, Protein, Random, Urine

Additional Codes

Mayo Test ID
REPU


Ordering Guidance


Random urine specimens may be sufficient for identifying monoclonal proteins, but 24-hour specimens should be used to quantitate and monitor urinary abnormalities. See MPSU / Monoclonal Protein Study, 24 Hour, Urine.



Shipping Instructions


Refrigerate specimen after collection and send refrigerated.



Necessary Information


 



Specimen Required


Supplies:

-Urine Container, 60 mL (T313)

-Aliquot Tube, 5 mL (T465)

Submission Container/Tube: Plastic, 60-mL urine bottle and plastic, 5-mL tube

Specimen Volume: 50 mL

Collection Instructions:

1. Collect random urine specimen.

2. Aliquot at least 25-mL specimen in plastic, 60-mL urine bottle and at least 1-mL of specimen in plastic, 5-mL tube.

3. Label specimens appropriately (60-mL bottle for protein electrophoresis and 5-mL tube for protein, total).


Useful For

Identifying monoclonal gammopathies using random urine specimens

Profile Information

Test ID Reporting Name Available Separately Always Performed
RPEU Protein Electrophoresis, Random, U No Yes
PTCON Protein, Total, Random, U No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
RIFXU Immunofixation, Random, U No No

Testing Algorithm

Urine protein electrophoresis alone is not considered an adequate screening for monoclonal gammopathies. If a discrete electrophoresis band is identified, the laboratory will evaluate the urine protein electrophoresis and, if necessary, perform immunofixation at an additional charge.

 

The following algorithms are available:

-Amyloidosis: Laboratory Approach to Diagnosis

-Multiple Myeloma: Laboratory Screening

Method Name

PTCON: Turbidimetry

RPEU: Agarose Gel Electrophoresis

RIFXU: Immunofixation

Reporting Name

Electrophoresis, Protein, Random, U

Specimen Type

Urine

Specimen Minimum Volume

25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  5 days
  Ambient  24 hours

Reference Values

PROTEIN, TOTAL

No reference values apply to random urine.

 

ELECTROPHORESIS, PROTEIN

The following fractions, if present, will be reported as mg/dL:

-Albumin

-Alpha-1-globulin

-Alpha-2-globulin

-Beta-globulin

-Gamma-globulin

No reference values apply to random urines.

Day(s) Performed

Total Protein: Monday through Sunday

Protein Electrophoresis: Monday through Friday

Report Available

4 to 6 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84156

84166

86335-Immunofixation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
REPU Electrophoresis, Protein, Random, U In Process

 

Result ID Test Result Name Result LOINC Value
PTCON Protein, Total, Random, U 2888-6
607975 Albumin 6942-7
607976 Alpha-1 globulin 9734-5
607977 Alpha-2 globulin 38190-5
607978 Beta globulin 9744-4
607979 Gamma globulin 9745-1
33044 A/G Ratio 44293-9
33045 M spike 40661-1
33046 M spike 40661-1
33047 Impression 49299-1