Neuroimmunology Antibody Follow-up, Serum

Reporting Name

Neuroimmunology Ab Follow-up, S

Useful For

Monitoring patients who have previously tested positive for one or more antibodies within the past 5 years in a Mayo Neuroimmunology Laboratory serum evaluation

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum

Ordering Guidance

This test is only appropriate for follow-up in patients who have previously tested positive in a serum test. If patients have not previously been positive in a serum test, order 1 of the following:

-PAVAL / Paraneoplastic, Autoantibody Evaluation, Serum

-GID2 / Autoimmune Gastrointestinal Dysmotility Evaluation, Serum

-DYS2 / Autoimmune Dysautonomia Evaluation, Serum

-DMS2 / Dementia, Autoimmune Evaluation, Serum

-ENS2 / Encephalopathy, Autoimmune Evaluation, Serum

-EPS2 / Epilepsy, Autoimmune Evaluation, Serum

-MDS2 / Movement Disorder, Autoimmune Evaluation, Serum

-MGLE / Myasthenia Gravis/Lambert-Eaton Myasthenic Syndrome Evaluation, Serum

-MGMR / Myasthenia Gravis Evaluation with Muscle-Specific Kinase (MuSK) Reflex, Serum

Specimen Required

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: 13- x 75-mm plastic screw-top vial.

Specimen Volume: 4 mL

Collection Instructions: Centrifuge within 2 hours. Aliquot and ship in 13- x 75-mm plastic screw-top vial.

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Refrigerated (preferred)	28 days
	Frozen	28 days
	Ambient	72 hours

Reference Values

Test ID	Reporting Name	Methodology	Reference Value
GANG	AChR Ganglionic Neuronal Ab, S	Radioimmunoassay (RIA)	≤0.02 nmol/L
ACMFS	AChR Modulating Flow Cytometry, S	Flow Cytometry (FACS)	Negative
AGNBS	AGNA-1 Immunoblot, S	Immunoblot (IB)	Negative
AINCS	Alpha Internexin CBA, S	Cell Binding Assay (CBA)	Negative
AMPCS	AMPA-R Ab CBA, S	CBA	Negative
AMPIS	AMPA-R Ab IF Titer Assay, S	Indirect Immunofluorescence Assay (IFA)	<1:120
AMPHS	Amphiphysin Ab, S	IFA	<1:240
AMIBS	Amphiphysin Immunoblot, S	IB	Negative
AN1BS	ANNA-1 Immunoblot, S	IB	Negative
AN2BS	ANNA-2 Immunoblot, S	IB	Negative
AGN1S	Anti-Glial Nuclear Ab, Type 1	IFA	<1:240
ANN1S	Anti-Neuronal Nuclear Ab, Type 1	IFA	<1:240
ANN2S	Anti-Neuronal Nuclear Ab, Type 2	IFA	<1:240
ANN3S	Anti-Neuronal Nuclear Ab, Type 3	IFA	<1:240
CS2CS	CASPR2-IgG CBA, S	CBA	Negative
CRMS	CRMP-5-IgG, S	IFA	<1:240
DPPCS	DPPX Ab CBA, S	CBA	Negative
DPPTS	DPPX Ab IFA Titer, S	IFA	<1:240
DPPIS	DPPX Ab IFA, S	IFA	<1:240
GABCS	GABA-B-R Ab CBA, S	CBA	Negative
GABIS	GABA-B-R Ab IF Titer Assay, S	IFA	<1:240
GFACS	GFAP CBA, S	CBA	Negative
GFATS	GFAP IFA Titer, S	IFA	<1:240
GFAIS	GFAP IFA, S	IFA	<1:240
GRFCS	GRAF1 CBA, S	CBA	Negative
GRFTS	GRAF1 IFA Titer, S	IFA	<1:240
GRFIS	GRAF1 IFA, S	IFA	<1:240
IGATS	IgG Asialo GM1 Titer, S	EIA	<1:16000
IGG_A	IgG Asialo. GM1	EIA	Negative
IGDTS	IgG Disialo GD1b Titer, S	EIA	<1:2000
IGG_D	IgG Disialo. GD1b	EIA	Negative
IGMTS	IgG Monos GM1 Titer, S	EIA	<1:2000
IG5CS	IgLON5 CBA, S	CBA	Negative
IG5TS	IgLON5 IFA Titer, S	IFA	<1:240
IG5IS	IgLON5 IFA, S	IFA	<1:240
IMATS	IgM Asialo GM1 Titer, S	EIA	<1:8000
IGM_A	IgM Asialo. GM1	EIA	Negative
IMDTS	IgM Disialo GD1b Titer, S	EIA	<1:2000
IGM_D	IgM Disialo. GD1b	EIA	Negative
IMMTS	IgM Monos GM1 Titer, S	EIA	<1:4000
IGM_M	IgM Monos. GM1	EIA	Negative
ITPCS	ITPR1 CBA, S	CBA	Negative
ITPTS	ITPR1 IFA Titer, S	IFA	<1:240
ITPIS	ITPR1 IFA, S	IFA	<1:240
LG1CS	LGI1-IgG CBA, S	CBA	Negative
GL1CS	mGluR1 Ab CBA, S	CBA	Negative
GL1TS	mGluR1 Ab IFA Titer, S	IFA	<1:240
GL1IS	mGluR1 Ab IFA, S	IFA	<1:240
VGKC	Neuronal (V-G) K+ Channel Ab, S	RIA	≤0.02 nmol/L
NFHCS	NIF Heavy Chain CBA, S	CBA	Negative
NIFTS	NIF IFA Titer, S	IFA	<1:240
NIFIS	NIF IFA, S	IFA	<1:240
NFLCS	NIF Light Chain CBA, S	CBA	Negative
NMDCS	NMDA-R Ab CBA, S	CBA	Negative
NMDIS	NMDA-R Ab IF Titer Assay, S	IFA	<1:240
CCN	N-Type Calcium Channel Ab	RIA	≤0.03 nmol/L
CCPQ	P/Q-Type Calcium Channel Ab	RIA	≤0.02 nmol/L
PC1BS	PCA-1 Immunoblot, S	IB	Negative
PCTBS	PCA-Tr Immunoblot, S	IB	Negative
PCABP	Purkinje Cell Cytoplasmic Ab Type 1	IFA	<1:240
PCAB2	Purkinje Cell Cytoplasmic Ab Type 2	IFA	<1:240
PCATR	Purkinje Cell Cytoplasmic Ab Type Tr	IFA	<1:240
SRPIS	SRP IFA Screen, S	IFA	<1:240
SRPTS	SRP IFA Titer, S	IFA	<1:240
SRPBS	SRP Immunoblot, S	IB	Negative

Day(s) Performed

GANG, VGKC, CCN, CCPQ:

Monday through Friday; 6 a.m., 8 a.m., 6 p.m.

Saturday, Sunday; 7 a.m.

ACMFS:

Monday, Wednesday, Saturday; 3 p.m.

AGNBS, AMIBS, AN1BS, AN2BS, PC1BS, PCTBS, SRPBS:

Monday through Friday; 6 p.m.

AINCS, NFHCS, NFLCS:

Tuesday, Thursday; 6 p.m.

AMPCS, CS2CS, DPPCS, GABCS, LG1CS, NMDCS:

Monday through Friday; 10 p.m.

Sunday; 3 p.m.

AMPIS, AMPHS, AGN1S, ANN1S, ANN2S, ANN3S, CRMS, DPPTS, DPPIS, GABIS, GFATS, GFAIS, GRFTS, GRFIS, IG5TS, IG5IS, ITPTS, ITPIS, GL1TS, GL1IS, NIFTS, NIFIS, NMDIS, PCABP, PCAB2, PCATR, SRPIS, SRPTS:

Monday through Friday; 5 a.m., 7 a.m., 5 p.m.

Saturday, Sunday; 6 a.m.

GFACS:

Monday, Wednesday, Friday; 6 p.m.

GRFCS, IG5CS, ITPCS, GL1CS:

Monday, Thursday; 6 p.m.

IGATS, IGG_A, IGDTS, IGG_D, IGMTS, IMA

CPT Code Information

83519-GANG (if appropriate)

86255-ACMFS (if appropriate)

84182-AGNBS (if appropriate)

86255-AINCS (if appropriate)

86255-AMPCS (if appropriate)

86256-AMPIS (if appropriate)

86255-AMPHS (if appropriate)

84182-AMIBS (if appropriate)

84182-AN1BS (if appropriate)

84182-AN2BS (if appropriate)

86255-AGN1S (if appropriate)

86255-ANN1S (if appropriate)

86255-ANN2S (if appropriate)

86255-ANN3S (if appropriate)

86255-CS2CS (if appropriate)

86255-CRMS (if appropriate)

86255-DPPCS (if appropriate)

86256-DPPTS (if appropriate)

86255-DPPIS (if appropriate)

86255-GABCS (if appropriate)

86256-GABIS (if appropriate)

86255-GFACS (if appropriate)

86256-GFATS (if appropriate)

86255-GFAIS (if appropriate)

86255-GRFCS (if appropriate)

86256-GRFTS (if appropriate)

86255-GRFIS (if appropriate)

83520-IGATS (if appropriate)

83516-IGG_A (if appropriate)

83520-IGDTS (if appropriate)

83516-IGG_D (if appropriate)

83520-IGMTS (if appropriate)

86255-IG5CS (if appropriate)

86256-IG5TS (if appropriate)

86255-IG5IS (if appropriate)

83520-IMATS (if appropriate)

83516-IGM_A (if appropriate)

83520-IMDTS (if appropriate)

83516-IGM_D (if appropriate)

83520-IMMTS (if appropriate)

83516-IGM_M (if appropriate)

86255-ITPCS (if appropriate)

86256-ITPTS (if appropriate)

86255-ITPIS (if appropriate)

86255-LG1CS (if appropriate)

86255-GL1CS (if appropriate)

86256-GL1TS (if appropriate)

86255-GL1IS (if appropriate)

83519-VGKC (if appropriate)

86255-NFHCS (if appropriate)

86256-NIFTS (if appropriate)

86255-NIFIS (if appropriate)

86255-NFLCS (if appropriate)

86255-NMDCS (if appropriate)

86256-NMDIS (if appropriate)

83519-CCN (if appropriate)

86596-CCPQ (if appropriate)

84182-PC1BS (if appropriate)

84182-PCTBS (if appropriate)

86255-PCABP (if appropriate)

86255-PCAB2 (if appropriate)

86255-PCATR (if appropriate)

86255-SRPIS (if appropriate)

86256-SRPTS (if appropriate)

84182-SRPBS (if appropriate)

LOINC Code Information

Test ID	Test Order Name	Order LOINC Value
PNEFS	Neuroimmunology Ab Follow-up, S	80615-8

Result ID	Test Result Name	Result LOINC Value
84300	Neuroimmunology Ab Follow-up, S	80615-8

Report Available

Varies

Reflex Tests

Test ID	Reporting Name	Available Separately	Always Performed
GANG	AChR Ganglionic Neuronal Ab, S	No	No
ACMFS	AChR Modulating Flow Cytometry, S	No	No
AGNBS	AGNA-1 Immunoblot, S	No	No
AINCS	Alpha Internexin CBA, S	No	No
AMPCS	AMPA-R Ab CBA, S	No	No
AMIBS	Amphiphysin Immunoblot, S	No	No
AN1BS	ANNA-1 Immunoblot, S	No	No
AN2BS	ANNA-2 Immunoblot, S	No	No
AGN1S	Anti-Glial Nuclear Ab, Type 1	No	No
ANN1S	Anti-Neuronal Nuclear Ab, Type 1	No	No
ANN2S	Anti-Neuronal Nuclear Ab, Type 2	No	No
ANN3S	Anti-Neuronal Nuclear Ab, Type 3	No	No
CS2CS	CASPR2-IgG CBA, S	No	No
CRMS	CRMP-5-IgG, S	No	No
DPPCS	DPPX Ab CBA, S	No	No
DPPTS	DPPX Ab IFA Titer, S	No	No
DPPIS	DPPX Ab IFA, S	No	No
GABCS	GABA-B-R Ab CBA, S	No	No
GABIS	GABA-B-R Ab IF Titer Assay, S	No	No
GFACS	GFAP CBA, S	No	No
GFATS	GFAP IFA Titer, S	No	No
GFAIS	GFAP IFA, S	No	No
GRFCS	GRAF1 CBA, S	No	No
GRFTS	GRAF1 IFA Titer, S	No	No
GRFIS	GRAF1 IFA, S	No	No
IGATS	IgG Asialo GM1 Titer, S	No	No
IGG_A	IgG Asialo. GM1	No	No
IGDTS	IgG Disialo GD1b Titer, S	No	No
IGG_D	IgG Disialo. GD1b	No	No
IGMTS	IgG Monos GM1 Titer, S	No	No
IG5CS	IgLON5 CBA, S	No	No
IG5TS	IgLON5 IFA Titer, S	No	No
IG5IS	IgLON5 IFA, S	No	No
IMATS	IgM Asialo GM1 Titer, S	No	No
IGM_A	IgM Asialo. GM1	No	No
IMDTS	IgM Disialo GD1b Titer, S	No	No
IGM_D	IgM Disialo. GD1b	No	No
IMMTS	IgM Monos GM1 Titer, S	No	No
IGM_M	IgM Monos. GM1	No	No
ITPCS	ITPR1 CBA, S	No	No
ITPTS	ITPR1 IFA Titer, S	No	No
ITPIS	ITPR1 IFA, S	No	No
LG1CS	LGI1-IgG CBA, S	No	No
GL1CS	mGluR1 Ab CBA, S	No	No
GL1TS	mGluR1 Ab IFA Titer, S	No	No
GL1IS	mGluR1 Ab IFA, S	No	No
VGKC	Neuronal (V-G) K+ Channel Ab, S	No	No
NFHCS	NIF Heavy Chain CBA, S	No	No
NIFTS	NIF IFA Titer, S	No	No
NIFIS	NIF IFA, S	No	No
NFLCS	NIF Light Chain CBA, S	No	No
NMDCS	NMDA-R Ab CBA, S	No	No
NMDIS	NMDA-R Ab IF Titer Assay, S	No	No
CCPQ	P/Q-Type Calcium Channel Ab	No	No
PC1BS	PCA-1 Immunoblot, S	No	No
PCTBS	PCA-Tr Immunoblot, S	No	No
PCABP	Purkinje Cell Cytoplasmic Ab Type 1	No	No
PCAB2	Purkinje Cell Cytoplasmic Ab Type 2	No	No
PCATR	Purkinje Cell Cytoplasmic Ab Type Tr	No	No
SRPIS	SRP IFA Screen, S	No	No
SRPTS	SRP IFA Titer, S	No	No
SRPBS	SRP Immunoblot, S	No	No

Method Name

AMPIS, AMPHS, AGN1S, ANN1S, ANN2S, ANN3S, CRMS, DPPTS, DPPIS, GABIS, GFATS, GFAIS, GRFTS, GRFIS, IG5TS, IG5IS, ITPTS, ITPIS, GL1TS, GL1IS, NIFTS, NIFIS, NMDIS, PCABP, PCAB2, PCATR, SRPIS, SRPTS: Indirect Immunofluorescence Assay (IFA)

AINCS, AMPCS, CS2CS, DPPCS, GABCS, GFACS, GRFCS, IG5CS, ITPCS, LG1CS, GL1CS, NFHCS, NFLCS, NMDCS: Cell Binding Assay (CBA)

CCPQ, GANG, VGKC: Radioimmunoassay (RIA)

ACMFS: Flow Cytometry (FACS)

IGATS, IGG_A, IGDTS, IGG_D, IGMTS, IMATS, IGM_A, IMDTS, IGM_D, IMMTS, IGM_M: Enzyme-linked Immunosorbent Assay (EIA)

AGNBS, AMIBS, AN1BS, AN2BS, PC1BS, PCTBS, SRPBS: Immunoblot (IB)

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.

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BCH Order Code PNEFS Neuroimmunology Antibody Follow-up, Serum